Air pollution exposure and telomere length in highly exposed subjects in Beijing, China: a repeated-measure study.

ABSTRACT:

Background

Ambient particulate matter (PM) exposure has been associated with short- and long-term effects on cardiovascular disease (CVD). Telomere length (TL) is a biomarker of CVD risk that is modified by inflammation and oxidative stress, two key pathways for PM effects. Whether PM exposure modifies TL is largely unexplored.

Objectives

To investigate effects of PM on blood TL in a highly-exposed population.

Methods

We measured blood TL in 120 blood samples from truck drivers and 120 blood samples from office workers in Beijing, China. We measured personal PM(2.5) and Elemental Carbon (EC, a tracer of traffic particles) using light-weight monitors. Ambient PM(10) was obtained from local monitoring stations. We used covariate-adjusted regression models to estimate pe

SUBMITTER: Hou L 

PROVIDER: S-EPMC3821920 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature