Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli.

ABSTRACT: Terminal differentiation requires molecules also involved in aging such as the cell cycle inhibitor p16(INK4a). Like other organs, the adult liver represents a quiescent organ with terminal differentiated cells, hepatocytes and cholangiocytes. These cells retain the ability to proliferate in response to liver injury or reduction of liver mass. However, under conditions which prevent mitotic activation of hepatocytes, regeneration can occur instead from facultative hepatic stem cells.For therapeutic application a non-toxic activation of this stem cell compartment is required. We have established transgenic mice with conditional overexpression of the cell cycle inhibitor p16(INK4a) in hepatocytes and have provoked and examined oval cell activation in adult liver in response to a range of pro

SUBMITTER: Ueberham E 

PROVIDER: S-EPMC3822548 | biostudies-literature | 2008 Apr

REPOSITORIES: biostudies-literature