A novel design of bioartificial kidneys with improved cell performance and haemocompatibility.

ABSTRACT: Treatment with bioartificial kidneys had beneficial effects in animal experiments and improved survival of critically ill patients with acute kidney injury in a Phase II clinical trial. However, a Phase II b clinical trial failed. This and other results suggested various problems with the current design of bioartificial kidneys. We propose a novel design to improve various properties of device, including haemocompatibility and cell performance. An important feature of the novel design is confinement of the blood to the lumina of the hollow fibre membranes. This avoids exposure of the blood to the non-haemocompatible outer surfaces of hollow fibre membranes, which usually occurs in bioartificial kidneys. We use these outer surfaces as substrate for cell growth. Our results show that commerc

SUBMITTER: Oo ZY 

PROVIDER: S-EPMC3822650 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature