Extensive variation and sub-structuring in lineage A mtDNA in Indian sheep: genetic evidence for domestication of sheep in India.

ABSTRACT: Previous studies on mitochondrial DNA analysis of sheep from different regions of the world have revealed the presence of two major- A and B, and three minor- C, D and E maternal lineages. Lineage A is more frequent in Asia and lineage B is more abundant in regions other than Asia. We have analyzed mitochondrial DNA sequences of 330 sheep from 12 different breeds of India. Neighbor-joining analysis revealed lineage A, B and C in Indian sheep. Surprisingly, multidimensional scaling plot based on FST values of control region of mtDNA sequences showed significant breed differentiation in contrast to poor geographical structuring reported earlier in this species. The breed differentiation in Indian sheep was essentially due to variable contribution of two major lineages to different breeds, an

SUBMITTER: Singh S 

PROVIDER: S-EPMC3823876 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature