Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway.
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ABSTRACT:
SUBMITTER: Ji Q
PROVIDER: S-EPMC3823921 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway.
Ji Qing Q Liu Xuan X Fu Xiaoling X Zhang Long L Sui Hua H Zhou Lihong L Sun Jian J Cai Jianfeng J Qin Jianmin J Ren Jianlin J Li Qi Q
PloS one 20131111 11
Resveratrol, extracted from Chinese herbal medicine Polygonum cuspidatum, is known to inhibit invasion and metastasis of human colorectal cancer (CRC), in which long non-coding Metastasis Associated Lung Adenocarcinoma Transcript 1 (RNA-MALAT1) also plays an important role. Using MALAT1 lentiviral shRNA and over-expression constructs in CRC derived cell lines, LoVo and HCT116, we demonstrated that the anti-tumor effects of resveratrol on CRC are through inhibiting Wnt/β-catenin signaling, thus t ...[more]
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