Orphan G protein-coupled receptor GPR116 regulates pulmonary surfactant pool size.

ABSTRACT: Pulmonary surfactant levels within the alveoli are tightly regulated to maintain lung volumes and promote efficient gas exchange across the air/blood barrier. Quantitative and qualitative abnormalities in surfactant are associated with severe lung diseases in children and adults. Although the cellular and molecular mechanisms that control surfactant metabolism have been studied intensively, the critical molecular pathways that sense and regulate endogenous surfactant levels within the alveolus have not been identified and constitute a fundamental knowledge gap in the field. In this study, we demonstrate that expression of an orphan G protein-coupled receptor, GPR116, in the murine lung is developmentally regulated, reaching maximal levels 1 day after birth, and is highly expressed on the a

SUBMITTER: Bridges JP 

PROVIDER: S-EPMC3824053 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature