Causal role of prefrontal cortex in strengthening of episodic memories through reconsolidation.

ABSTRACT: Memory consolidation is a dynamic process. Reactivation of consolidated memories triggers reconsolidation, a time-limited period during which memories can be modified. Episodic memory refers to our ability to recall specific past events about what happened, including where and when. However, it is unknown whether noninvasive stimulation of the neocortex during reconsolidation might strengthen existing episodic memories in humans. To modify these memories, we applied repetitive transcranial magnetic stimulation (rTMS) over right lateral prefrontal cortex (PFC), a region involved in the reactivation of episodic memories. We report that rTMS of PFC after memory reactivation strengthened verbal episodic memories, an effect documented by improved recall 24 hr postreactivation compared to stimul

SUBMITTER: Sandrini M 

PROVIDER: S-EPMC3824257 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature