Germline prognostic markers for urinary bladder cancer: obstacles and opportunities.

ABSTRACT: Urinary bladder cancer is a heterogeneous disease with diverse genetic and environmental risk factors that can influence disease risk or clinical course for recurrence, progression, and survival. Therefore, identification of these factors is paramount for disease prevention and optimal clinical management of bladder cancer patients. Of particular interest is the need to identify molecular biomarkers that can give accurate assessment of tumor biological potential and to predict treatment response. Recent advances in molecular biology, cytogenetic, and genomic research have spurred discovery efforts for novel genetic, epigenetic, and proteomic biomarkers that are prognostic for cancer. This review focuses on some of the important germ line polymorphisms found to be correlated with clinical o

SUBMITTER: Chang DW 

PROVIDER: S-EPMC3824379 | biostudies-literature | 2012 Jul-Aug

REPOSITORIES: biostudies-literature