Genetic susceptibility to obesity and diet intakes: association and interaction analyses in the Malmo Diet and Cancer Study.

ABSTRACT: Gene-environment interactions need to be studied to better understand the obesity. We aimed at determining whether genetic susceptibility to obesity associates with diet intake levels and whether diet intakes modify the genetic susceptibility. In 29,480 subjects of the population-based Malmö Diet and Cancer Study (MDCS), we first assessed association between 16 genome-wide association studies identified obesity-related single-nucleotide polymorphisms (SNPs) with body mass index (BMI) and associated traits. We then conducted association analyses between a genetic risk score (GRS) comprising of 13 replicated SNPs and the individual SNPs, and relative dietary intakes of fat, carbohydrates, protein, fiber and total energy intake, as well as interaction analyses on BMI and associated traits amo

SUBMITTER: Rukh G 

PROVIDER: S-EPMC3824829 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature