Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry.

ABSTRACT:

Background

Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk.

Objective

To examine the joint effects of several type 2 diabetes risk variants and their combination with conventional risk factors on type 2 diabetes risk in 2 prospective cohorts.

Design

Nested case-control study.

Setting

United States.

Participants

2809 patients with type 2 diabetes and 3501 healthy control participants of European ancestry from the Health Professionals Follow-up Study and Nurses' Health Study.

Measurements

A genetic risk score (GRS) was calculated on the basis of 10 polymorphisms in 9 loci.

Results

After adjustment for age and body mass index (BMI), the odds ratio for type 2 diabetes with ea

SUBMITTER: Cornelis MC 

PROVIDER: S-EPMC3825275 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature