Association of restless legs syndrome variants in Korean patients with restless legs syndrome.

ABSTRACT:

Study objectives

Recent genome-wide association studies (GWAS) for Caucasians identified several allelic variants associated with increased risk of developing restless legs syndrome (RLS), also known as Willis-Ekbom disease. Although the pathogenic mechanisms of RLS are not entirely understood, it is becoming increasingly evident that many diseases such as RLS can be attributed to an epistasis. The study objectives were to evaluate whether the associations of RLS with all loci determined in previous GWAS for Caucasians can be replicated significantly for the Korean population and to elucidate whether an epistasis plays a role in the pathogenesis of RLS.

Design setting and participants

DNA from 320 patients with RLS and 320 age- and sex-matched controls were genotyped for var

SUBMITTER: Kim MK 

PROVIDER: S-EPMC3825427 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature