Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression.

ABSTRACT:

Objective

Although substantial literature has reported regional cerebral blood flow (rCBF) abnormalities in adults with depression, these studies commonly necessitated the injection of radioisotopes into subjects. The recent development of arterial spin labeling (ASL), however, allows noninvasive measurements of rCBF. Currently, no published ASL studies have examined cerebral perfusion in adolescents with depression. Thus, the aim of the present study was to examine baseline cerebral perfusion in adolescent depression using a newly developed ASL technique: pseudocontinuous arterial spin labeling (PCASL).

Method

A total of 25 medication-naive adolescents (13-17 years of age) diagnosed with major depressive disorder (MDD) and 26 well-matched control subjects underwent function

SUBMITTER: Ho TC 

PROVIDER: S-EPMC3825460 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature