Antibody persistence and immunologic memory after sequential pneumococcal conjugate and polysaccharide vaccination in HIV-infected children on highly active antiretroviral therapy.

ABSTRACT:

Background

The capacity of pneumococcal vaccination to confer memory in HIV-infected children is critical for durable protection.

Methods

HIV-infected children 2-<19 years administered two doses of pneumococcal conjugate vaccine (PCV7) and one dose of polysaccharide vaccine (PPV) on HAART were randomized 4-5 years later to receive a PCV7 or PPV booster. Total and high avidity antibodies to serotypes 1 (PPV) and 6B and 14 (PCV7 and PPV) were determined by ELISA. Memory was defined as persistence of ≥ 0.5 mcg/mL of serotype-specific antibody on day 0 or change from <0.5 mcg/mL to ≥ 0.5 mcg/mL between day 0 and week 1, or, ≥ 4-fold antibody rise between day 0 and week 1.

Results

Prior to boosting, 4-5 years after the previous PCV7-PCV7-PPV series, geometric mean concentr

SUBMITTER: Abzug MJ 

PROVIDER: S-EPMC3825555 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature