Metabolomics identifies a biological response to chronic low-dose natural uranium contamination in urine samples.

ABSTRACT: Because uranium is a natural element present in the earth's crust, the population may be chronically exposed to low doses of it through drinking water. Additionally, the military and civil uses of uranium can also lead to environmental dispersion that can result in high or low doses of acute or chronic exposure. Recent experimental data suggest this might lead to relatively innocuous biological reactions. The aim of this study was to assess the biological changes in rats caused by ingestion of natural uranium in drinking water with a mean daily intake of 2.7 mg/kg for 9 months and to identify potential biomarkers related to such a contamination. Subsequently, we observed no pathology and standard clinical tests were unable to distinguish between treated and untreated animals. Conversely, L

SUBMITTER: Grison S 

PROVIDER: S-EPMC3825637 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature