Predictors of response to tiotropium versus salmeterol in asthmatic adults.

ABSTRACT:

Background

Tiotropium has activity as an asthma controller. However, predictors of a positive response to tiotropium have not been described.

Objective

We sought to describe individual and differential responses of asthmatic patients to salmeterol and tiotropium when added to an inhaled corticosteroid, as well as predictors of a positive clinical response.

Methods

Data from the double-blind, 3-way, crossover National Heart, Lung, and Blood Institute's Asthma Clinical Research Network's Tiotropium Bromide as an Alternative to Increased Inhaled Glucocorticoid in Patients Inadequately Controlled on a Lower Dose of Inhaled Corticosteroid (ClinicalTrials.gov number, NCT00565266) trial were analyzed for individual and differential treatment responses to salmeterol and tiotr

SUBMITTER: Peters SP 

PROVIDER: S-EPMC3826080 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature