Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers.

ABSTRACT:

Rationale

Previous studies of chronic obstructive pulmonary disease (COPD) have suggested that genetic factors play an important role in the development of disease. However, single-nucleotide polymorphisms that are associated with COPD in genome-wide association studies have been shown to account for only a small percentage of the genetic variance in phenotypes of COPD, such as spirometry and imaging variables. These phenotypes are highly predictive of disease, and family studies have shown that spirometric phenotypes are heritable.

Objectives

To assess the heritability and coheritability of four major COPD-related phenotypes (measurements of FEV1, FEV1/FVC, percent emphysema, and percent gas trapping), and COPD affection status in smokers of non-Hispanic white and African A

SUBMITTER: Zhou JJ 

PROVIDER: S-EPMC3826281 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature