Soluble CD14: genomewide association analysis and relationship to cardiovascular risk and mortality in older adults.

ABSTRACT:

Objective

CD14 is a glycosylphosphotidylinositol-anchored membrane glycoprotein expressed on neutrophils and monocytes/macrophages that also circulates as a soluble form (sCD14). Despite the well-recognized role of CD14 in inflammation, relatively little is known about the genetic determinants of sCD14 or the relationship of sCD14 to vascular- and aging-related phenotypes.

Methods and results

We measured baseline levels of sCD14 in >5000 European-American and black adults aged 65 years and older from the Cardiovascular Health Study, who were well characterized at baseline for atherosclerotic risk factors and subclinical cardiovascular disease, and who have been followed for clinical cardiovascular disease and mortality outcomes up to 20 years. At baseline, sCD14 generally sh

SUBMITTER: Reiner AP 

PROVIDER: S-EPMC3826541 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature