Metabolic syndrome remodels electrical activity of the sinoatrial node and produces arrhythmias in rats.

ABSTRACT: In the last ten years, the incidences of metabolic syndrome and supraventricular arrhythmias have greatly increased. The metabolic syndrome is a cluster of alterations, which include obesity, hypertension, hypertriglyceridemia, glucose intolerance and insulin resistance, that increase the risk of developing, among others, atrial and nodal arrhythmias. The aim of this study is to demonstrate that metabolic syndrome induces electrical remodeling of the sinus node and produces arrhythmias. We induced metabolic syndrome in 2-month-old male Wistar rats by administering 20% sucrose in the drinking water. Eight weeks later, the rats were anesthetized and the electrocardiogram was recorded, revealing the presence of arrhythmias only in treated rats. Using conventional microelectrode and voltage cl

SUBMITTER: Albarado-Ibanez A 

PROVIDER: S-EPMC3826723 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature