Architecture and gene repertoire of the flexible genome of the extreme acidophile Acidithiobacillus caldus.

ABSTRACT:

Background

Acidithiobacillus caldus is a sulfur oxidizing extreme acidophile and the only known mesothermophile within the Acidithiobacillales. As such, it is one of the preferred microbes for mineral bioprocessing at moderately high temperatures. In this study, we explore the genomic diversity of A. caldus strains using a combination of bioinformatic and experimental techniques, thus contributing first insights into the elucidation of the species pangenome.

Principal findings

Comparative sequence analysis of A. caldus ATCC 51756 and SM-1 indicate that, despite sharing a conserved and highly syntenic genomic core, both strains have unique gene complements encompassing nearly 20% of their respective genomes. The differential gene complement of each strain is distributed betwe

SUBMITTER: Acuna LG 

PROVIDER: S-EPMC3826726 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature