Association of the glutathione s-transferase m1, t1 polymorphisms with cancer: evidence from a meta-analysis.

ABSTRACT:

Background

Glutathione S-transferases (GSTs) are a family of multifunctional enzymes that are involved in the metabolism of many xenobiotics, including a wide range of environmental carcinogens. While the null genotypes in GSTM1 and GSTT1 have been implicated in tumorigenesis, it remains inconsistent and inconclusive. Herein, we aimed to assess the possible associations of the GSTM1 and GSTT1 null genotype in cancer risks.

Methods

A meta-analysis based on 506 case-control studies was performed. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association.

Results

The null genotypes of GSTM1 and GSTT1 polymorphisms were associated with a significantly increased risk in cancer (for GSTM1: OR = 1.17; 95%CI = 1.14-1.21; for GSTT1:

SUBMITTER: Fang J 

PROVIDER: S-EPMC3826727 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature