Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lung.

ABSTRACT: Studies have indicated increased incidence and severity of allergic asthma due to western lifestyle and increased sedentary activity. Investigations also indicate that exercise reduces the severity of asthma; however, a mechanism of action has not been elucidated. Additional work implicates re-distribution of T helper (Th) cells in mediating alterations of the immune system as a result of moderate aerobic exercise in vivo. We have previously reported that exercise decreases T helper 2 (Th2) responses within the lungs of an ovalbumin (OVA)-sensitized murine allergic asthma model. Therefore, we hypothesized that exercise alters the migration of OVA-specific Th cells in an OVA-challenged lung. To test this hypothesis, wildtype mice received OVA-specific Th cells expressing a luciferase-report

SUBMITTER: Dugger KJ 

PROVIDER: S-EPMC3826814 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature