Ontology highlight
ABSTRACT:
SUBMITTER: Ghajar CM
PROVIDER: S-EPMC3826912 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Nature cell biology 20130602 7
In a significant fraction of breast cancer patients, distant metastases emerge after years or even decades of latency. How disseminated tumour cells (DTCs) are kept dormant, and what wakes them up, are fundamental problems in tumour biology. To address these questions, we used metastasis assays in mice and showed that dormant DTCs reside on microvasculature of lung, bone marrow and brain. We then engineered organotypic microvascular niches to determine whether endothelial cells directly influenc ...[more]