Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.

ABSTRACT: Directional cell movement is universally required for tissue morphogenesis. Although it is known that cell/matrix interactions are essential for directional movement in heart development, the mechanisms governing these interactions require elucidation. Here we demonstrate that a novel protein/protein interaction between blood vessel epicardial substance (Bves) and N-myc downstream regulated gene 4 (NDRG4) is critical for regulation of epicardial cell directional movement, as disruption of this interaction randomizes migratory patterns. Our studies show that Bves/NDRG4 interaction is required for trafficking of internalized fibronectin through the "autocrine extracellular matrix (ECM) deposition" fibronectin recycling pathway. Of importance, we demonstrate that Bves/NDRG4-mediated fibronect

SUBMITTER: Benesh EC 

PROVIDER: S-EPMC3826988 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature