Homology blocks of Plasmodium falciparum var genes and clinically distinct forms of severe malaria in a local population.

ABSTRACT:

Background

The primary target of the human immune response to the malaria parasite Plasmodium falciparum, P. falciparum erythrocyte membrane protein 1 (PfEMP1), is encoded by the members of the hyper-diverse var gene family. The parasite exhibits antigenic variation via mutually exclusive expression (switching) of the ~60 var genes within its genome. It is thought that different variants exhibit different host endothelial binding preferences that in turn result in different manifestations of disease.

Results

Var sequences comprise ancient sequence fragments, termed homology blocks (HBs), that recombine at exceedingly high rates. We use HBs to define distinct var types within a local population. We then reanalyze a dataset that contains clinical and var expression data to inv

SUBMITTER: Rorick MM 

PROVIDER: S-EPMC3827005 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature