Paraoxonase 1 polymorphisms and risk of myocardial infarction in women and men.

ABSTRACT:

Background

Previous studies of genetic variants of paraoxonase 1 (PON1) and coronary heart disease (CHD) have been conflicting and the modifying effects of lifestyle factors that affect PON1 activity are uncertain.

Methods and results

In parallel nested case-control studies, the prospective associations between PON1 polymorphisms Q192R and L55M and incident CHD were examined among participants in the Nurses' Health and Health Professionals Follow-up Studies. Women were followed for 8 years and men for 6 years, and 249 women and 266 men were documented with incident CHD. Neither polymorphism was associated with risk of CHD in either sex, and neither monounsaturated fat intake nor smoking interacted with genotype. Among women, there was a possible interaction of Q192R with alc

SUBMITTER: Mukamal KJ 

PROVIDER: S-EPMC3827025 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature