S6 peptide derived from KvAP channel shows cooperativity in gating on bilayer lipid membrane.

ABSTRACT: Collective behavior of S6 peptide channels derived from KvAP (a bacterial potassium channel) incorporated in lipid bilayer membrane, has been investigated at various applied potentials through multi-channel electrophysiological experiments. The current versus time traces at any particular membrane potential show clear steps for sequential opening of the multi-channels. The minimum current (representing one-channel current) was found out from the amplitude histograms. Accordingly, the number of open channels corresponding to a particular open state was calculated. It was observed that the above-mentioned one channel current is higher than the corresponding single-channel current at most of the applied membrane potentials. Moreover, the difference between the single and one channel conductan

SUBMITTER: Malik C 

PROVIDER: S-EPMC3827124 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature