Age-related expression of the polymeric immunoglobulin receptor (pIgR) in the gastric mucosa of young pigs.

ABSTRACT: To date few studies have addressed the development and function of the porcine gastric mucosal immune system and this is a major limitation to understanding the immunopathogenesis of infections occurring in young pigs. The polymeric immunoglobulin receptor (pIgR) mediates the transport of secretory immunoglobulins until luminal surface of the gut mucosa and the aim of this study was to investigate the time course of pIgR expression and to determine its localization in three functionally different porcine gastric sites during the suckling period and after weaning. An additional goal was to investigate the time course expression of toll-like receptors (TLRs) in relation to pIgR expression. Gastric samples were collected from the cardiac-to-oxyntic transition (Cd), the oxyntic (Ox), and the p

SUBMITTER: Trevisi P 

PROVIDER: S-EPMC3827463 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature