Deep insights into Dictyocaulus viviparus transcriptomes provides unique prospects for new drug targets and disease intervention.

ABSTRACT: The lungworm, Dictyocaulus viviparus, causes parasitic bronchitis in cattle, and is responsible for substantial economic losses in temperate regions of the world. Here, we undertake the first large-scale exploration of available transcriptomic data for this lungworm, examine differences in transcription between different stages/both genders and identify and prioritize essential molecules linked to fundamental metabolic pathways, which could represent novel drug targets. Approximately 3 million expressed sequence tags (ESTs), generated by 454 sequencing from third-stage larvae (L3s) as well as adult females and males of D. viviparus, were assembled and annotated. The assembly of these sequences yielded ~61,000 contigs, of which relatively large proportions encoded collagens (4.3%), ubiquiti

SUBMITTER: Cantacessi C 

PROVIDER: S-EPMC3827682 | biostudies-literature | 2011 May-Jun

REPOSITORIES: biostudies-literature