Ontology highlight
ABSTRACT:
SUBMITTER: Pan B
PROVIDER: S-EPMC3827726 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Pan Bifeng B Géléoc Gwenaelle S GS Asai Yukako Y Horwitz Geoffrey C GC Kurima Kiyoto K Ishikawa Kotaro K Kawashima Yoshiyuki Y Griffith Andrew J AJ Holt Jeffrey R JR
Neuron 20130718 3
Sensory transduction in auditory and vestibular hair cells requires expression of transmembrane channel-like (Tmc) 1 and 2 genes, but the function of these genes is unknown. To investigate the hypothesis that TMC1 and TMC2 proteins are components of the mechanosensitive ion channels that convert mechanical information into electrical signals, we recorded whole-cell and single-channel currents from mouse hair cells that expressed Tmc1, Tmc2, or mutant Tmc1. Cells that expressed Tmc2 had high calc ...[more]