Knowledge-based compact disease models identify new molecular players contributing to early-stage Alzheimer's disease.

ABSTRACT:

Background

High-throughput profiling of human tissues typically yield as results the gene lists comprised of a mix of relevant molecular entities with multiple false positives that obstruct the translation of such results into mechanistic hypotheses. From general probabilistic considerations, gene lists distilled for the mechanistically relevant components can be far more useful for subsequent experimental design or data interpretation.

Results

The input candidate gene lists were processed into different tiers of evidence consistency established by enrichment analysis across subsets of the same experiments and across different experiments and platforms. The cut-offs were established empirically through ontological and semantic enrichment; resultant shortened gene list was re

SUBMITTER: Mayburd A 

PROVIDER: S-EPMC3827844 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature