Detection of serological biomarkers by proximity extension assay for detection of colorectal neoplasias in symptomatic individuals.

ABSTRACT:

Background

Although the potential of biomarkers to aid in early detection of colorectal cancer (CRC) is recognized and numerous biomarker candidates have been reported in the literature, to date only few molecular markers have been approved for daily clinical use.

Methods

In order to improve the translation of biomarkers from the bench to clinical practice we initiated a biomarker study focusing on a novel technique, the proximity extension assay, with multiplexing capability and the possible additive effect obtained from biomarker panels. We performed a screening of 74 different biomarkers in plasma derived from a case-control sample set consisting of symptomatic individuals representing CRC patients, patients with adenoma, patients with non-neoplastic large bowel diseases

SUBMITTER: Thorsen SB 

PROVIDER: S-EPMC3827929 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature