Exploring fold space preferences of new-born and ancient protein superfamilies.

ABSTRACT: The evolution of proteins is one of the fundamental processes that has delivered the diversity and complexity of life we see around ourselves today. While we tend to define protein evolution in terms of sequence level mutations, insertions and deletions, it is hard to translate these processes to a more complete picture incorporating a polypeptide's structure and function. By considering how protein structures change over time we can gain an entirely new appreciation of their long-term evolutionary dynamics. In this work we seek to identify how populations of proteins at different stages of evolution explore their possible structure space. We use an annotation of superfamily age to this space and explore the relationship between these ages and a diverse set of properties pertaining to a su

SUBMITTER: Edwards H 

PROVIDER: S-EPMC3828129 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature