Impact of Il28b-related single nucleotide polymorphisms on liver transient elastography in chronic hepatitis C infection.

ABSTRACT:

Background and aims

Recently, several genome-wide association studies have revealed that single nucleotide polymorphisms (SNPs) in proximity to IL28B predict spontaneous clearance of hepatitis C virus (HCV) infection as well as outcome following pegylated interferon and ribavirin therapy among genotype 1 infected patients. Additionally the presence of the otherwise favorable IL28B genetic variants in the context of HCV genotype 3 infection reportedly entail more pronounced liver fibrosis and steatosis. The present study aimed to evaluate the impact of IL28B SNP variability on liver stiffness as accessed by transient elastography.

Methods

Seven hundred and seventy-one Swedish HCV infected patients sequentially undergoing liver stiffness measurement by means of Fibroscan® in t

SUBMITTER: Ydreborg M 

PROVIDER: S-EPMC3828208 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature