Linear decay of retrotransposon antisense bias across genes is contingent upon tissue specificity.

ABSTRACT: Retrotransposons comprise approximately half of the human genome and contribute to chromatin structure, regulatory motifs, and protein-coding sequences. Since retrotransposon insertions can disrupt functional genetic elements as well as introduce new sequence motifs to a region, they have the potential to affect the function of genes that harbour insertions as well as those nearby. Partly as a result of these effects, the distribution of retrotransposons across the genome is non-uniform and there are observed imbalances in the orientation of insertions with respect to the transcriptional direction of the containing gene. Although some of the factors underlying the observed distributions are understood, much of the variability remains unexplained. Detailed characterization of retrotransposo

SUBMITTER: Linker S 

PROVIDER: S-EPMC3828378 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature