Structural and biomechanical responses of osseous healing: a novel murine nonunion model.

ABSTRACT:

Background

Understanding the biological mechanisms of why certain fractures are at risk for delayed healing or nonunion requires translational animal models that take advantage of transgenic and other genetic manipulation technologies. Reliable murine nonunion models can be an important tool to understand the biology of nonunion. In this study, we report the results of a recently established model for creating critical defects that lead to atrophic nonunions based on a unique fracture fixation technique.

Materials and methods

Subcritical (0.6 mm long) and critical (1.6 mm long) defects were created in femurs of 10-week-old double transgenic (Col1/Col2) mice and stabilized using a custom-designed plate and four screws. Four groups were used: normal, sham, subcritical, and cri

SUBMITTER: Chaubey A 

PROVIDER: S-EPMC3828495 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature