Drosophila importin-7 functions upstream of the Elmo signaling module to mediate the formation and stability of muscle attachments.

ABSTRACT: Establishment and maintenance of stable muscle attachments is essential for coordinated body movement. Studies in Drosophila have pioneered a molecular understanding of the morphological events in the conserved process of muscle attachment formation, including myofiber migration, muscle-tendon signaling, and stable junctional adhesion between muscle cells and their corresponding target insertion sites. In both Drosophila and vertebrate models, integrin complexes play a key role in the biogenesis and stability of muscle attachments through the interactions of integrins with extracellular matrix (ECM) ligands. We show that Drosophila importin-7 (Dim7) is an upstream regulator of the conserved Elmo-Mbc→Rac signaling pathway in the formation of embryonic muscle attachment sites (MASs). Dim7 is

SUBMITTER: Liu ZC 

PROVIDER: S-EPMC3828592 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature