Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti.

ABSTRACT: Dramatic structural changes in microtubules (MT) and the assembly of complicated intercellular connections are seen during the development of the cellular matrix of the sense organ for hearing, the organ of Corti. This report examines the expression of marshalin, a minus-end binding protein, during this process of cochlear development. We discovered that marshalin is abundantly expressed in both sensory hair cells and supporting cells. In the adult, prominent marshalin expression is observed in the cuticular plates of hair cells and in the noncentrosomal MT organization centers (MTOC) of Deiters' and pillar cells. Based upon differences in marshalin expression patterns seen in the organ of Corti, we identified eight isoforms ranging from 863 to 1280 amino acids. mRNAs/proteins associated w

SUBMITTER: Zheng J 

PROVIDER: S-EPMC3828766 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature