Loss of MTG16a (CBFA2T3), a novel rDNA repressor, leads to increased ribogenesis and disruption of breast acinar morphogenesis.
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ABSTRACT:
SUBMITTER: Rossetti S
PROVIDER: S-EPMC3828852 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
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Loss of MTG16a (CBFA2T3), a novel rDNA repressor, leads to increased ribogenesis and disruption of breast acinar morphogenesis.
Rossetti Stefano S Hoogeveen André T AT Esposito Joseph J Sacchi Nicoletta N
Journal of cellular and molecular medicine 20091202 6A
Human MTG16a (CBFA2T3), a chromatin repressor with nucleolar localization, was described to act as a suppressor of breast tumourigenesis. Here we show that MTG16a is a novel ribosomal gene repressor, which can counteract MYC-driven activation of ribosomal RNA (rRNA) transcription. We also show that either knocking down MTG16a by RNA interference, or sequestering MTG16a outside the nucleolus of human breast epithelial cells, hampers acinar morphogenesis concomitant with up-regulation of rRNA synt ...[more]
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