CX3CL1/fractalkine shedding by human hepatic stellate cells: contribution to chronic inflammation in the liver.

ABSTRACT: Chemokines are the inflammatory mediators that modulate liver fibrosis, a common feature of chronic inflammatory liver diseases. CX3CL1/fractalkine is a membrane-associated chemokine that requires step processing for chemotactic activity and has been recently implicated in liver disease. Here, we investigated the potential shedding activities involved in the release of the soluble chemotactic peptides from CX3CL1 in the injured liver. We showed an increased expression of the sheddases ADAM10 and ADAM17 in patients with chronic liver diseases that was associated with the severity of liver fibrosis. We demonstrated that hepatic stellate cells (HSC) were an important source of ADAM10 and ADAM17 and that treatment with the inflammatory cytokine inter-feron-gamma induced the expression of CX3CL

SUBMITTER: Bourd-Boittin K 

PROVIDER: S-EPMC3828864 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature