DNMT1 and AIM1 Imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation.

ABSTRACT:

Background

Genomic imprinting is an epigenetically regulated process wherein genes are expressed in a parent-of-origin specific manner. Many imprinted genes were initially identified in mice; some of these were subsequently shown not to be imprinted in humans. Such discrepancy reflects developmental, morphological and physiological differences between mouse and human tissues. This is particularly relevant for the placenta. Study of genomic imprinting thus needs to be carried out in a species and developmental stage-specific manner. We describe here a new strategy to study allele-specific DNA methylation in the human placenta for the discovery of novel imprinted genes.

Results

Using this methodology, we confirmed 16 differentially methylated regions (DMRs) associated with kno

SUBMITTER: Das R 

PROVIDER: S-EPMC3829101 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature