SAA1 gene variants and childhood obesity in China.

ABSTRACT:

Background

Obesity increases the risk for insulin resistance and metabolic syndrome in both adults and children. SAA is a member of apolipoprotein and plays an important role in maintaining glucose and lipid homeostasis. The purpose of this study was to assess SAA1 allelic variants with obesity in young school-age children.

Methods

A total of 520 consecutive children ages 5-15 years were recruited. Children were divided based on BMI z score into Obese (OB; BMI z score ≥1.65; n = 253) and non-obese (NOB; n = 267). Four SNPs of the human SAA1 gene (rs12218, rs4638289, rs7131332 and rs11603089) were genotyped by use of polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method.

Results

Compared to NOB, circulating SAA levels were increased in

SUBMITTER: Zhang X 

PROVIDER: S-EPMC3829107 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature