IL-7R α polymorphisms in 60 Iranian multiple sclerosis patients.

ABSTRACT:

Background

Multiple sclerosis (MS), a chronic inflammatory demyelinating disorder with neurodegenerative aspects, is more common among young adults, particularly women.

Methods

This molecular study was designed to investigate the IL-7R α chain gene in Iranian MS patients. We studied 60 MS patients, diagnosed based on 2005 R-McDonald criteria and 60 apparently healthy individuals as the control group. DNA was extracted from whole blood cells using MBST/IRAN Extraction kit and all samples were screened for possible sequence variation in three regions including promoter, exon 2 and exon 4 with single strand conformation polymorphism (SSCP).

Results

The alterations were confirmed with direct sequencing by ABI 3730XL. Although no mutation was detected in the studied region

SUBMITTER: Raji MA 

PROVIDER: S-EPMC3829237 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature