Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival.

ABSTRACT:

Background

Extensive evidence implicates the Eph receptor family of tyrosine kinases and its ligand, ephrin, in glioma invasion, but it remains incompletely understood how these receptors affect chemotactic behavior of glioma. We sought to identify the Eph family members that correlate with patients' survival and to reveal the function of Eph in glioma invasion.

Methods

Clinical relevance of EphB genes was confirmed in a clinically annotated expression data set of 195 brain biopsy specimens. The function of EphB was analyzed in vitro and in vivo.

Results

Levels of mRNA of certain EphB members were significantly different in histological grades of glioma. According to Kaplan-Meier analysis, only the EphB1 level among 5 members of EphB emerged to be a powerful predictor

SUBMITTER: Teng L 

PROVIDER: S-EPMC3829595 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature