Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.

ABSTRACT: Shields down! Adjuvant molecules that have the ability to restore the susceptibility of multi-drug-resistant bacteria, such as MRSA, to clinically available antibiotics are a promising alternative to the development of novel antimicrobials. Pictured is a potent small molecule (1) that, at sub-minimum inhibitory concentration (sub-MIC) levels, lowers the MIC of oxacillin (2) against a number of MRSA strains by up to 512-fold.

SUBMITTER: Harris TL 

PROVIDER: S-EPMC3829614 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature