Ontology highlight
ABSTRACT:
SUBMITTER: Ridaura VK
PROVIDER: S-EPMC3829625 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Ridaura Vanessa K VK Faith Jeremiah J JJ Rey Federico E FE Cheng Jiye J Duncan Alexis E AE Kau Andrew L AL Griffin Nicholas W NW Lombard Vincent V Henrissat Bernard B Bain James R JR Muehlbauer Michael J MJ Ilkayeva Olga O Semenkovich Clay F CF Funai Katsuhiko K Hayashi David K DK Lyle Barbara J BJ Martini Margaret C MC Ursell Luke K LK Clemente Jose C JC Van Treuren William W Walters William A WA Knight Rob R Newgard Christopher B CB Heath Andrew C AC Gordon Jeffrey I JI
Science (New York, N.Y.) 20130901 6150
The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free mice fed low-fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet. Increased total body and fat mass, as well as obesity-associated metabolic phenotypes, were transmissible with uncultured fecal communities and with their correspondi ...[more]