Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT).

ABSTRACT:

Objective

To determine whether there is a benefit in clinical outcomes with the use of topical corticosteroids as adjunctive therapy in the treatment of bacterial corneal ulcers.

Methods

Randomized, placebo-controlled, double-masked, multicenter clinical trial comparing prednisolone sodium phosphate, 1.0%, to placebo as adjunctive therapy for the treatment of bacterial corneal ulcers. Eligible patients had a culture-positive bacterial corneal ulcer and received topical moxifloxacin for at least 48 hours before randomization.

Main outcome measures

The primary outcome was best spectacle-corrected visual acuity (BSCVA) at 3 months from enrollment. Secondary outcomes included infiltrate/scar size, reepithelialization, and corneal perforation.

Results

Between Septem

SUBMITTER: Srinivasan M 

PROVIDER: S-EPMC3830549 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature