Rational Helicobacter pylori therapy: evidence-based medicine rather than medicine-based evidence.

ABSTRACT: Data are available such that choice of Helicobacter pylori therapy for an individual patient can be reliably predicted. Here, treatment success is defined as a cure rate of 90% or greater. Treatment outcome in a population or a patient can be calculated based on the effectiveness of a regimen for infections with susceptible and with resistant strains coupled with the knowledge of the prevalence of resistance (ie, based on formal measurement, clinical experience, or both). We provide the formula for predicting outcome and we illustrate the calculations. Because clarithromycin-containing triple therapy and 10-day sequential therapy are now only effective in special populations, they are considered obsolete; neither should continue to be used as empiric therapies (ie, 7- and 14-day triple the

SUBMITTER: Graham DY 

PROVIDER: S-EPMC3830667 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature