Synthesis and orthogonal photopatterning of hyaluronic acid hydrogels with thiol-norbornene chemistry.

ABSTRACT: The patterning of chemical and mechanical signals within hydrogels permits added complexity towards their use as cell microenvironments for biomedical applications. Specifically, photopatterning is emerging to introduce heterogeneity in hydrogel properties; however, currently employed systems are limited in the range of properties that can be obtained, as well as in decoupling mechanical properties from changes in chemical signals. Here, we present an orthogonal photopatterning system that utilizes thiol-norbornene chemistry and permits extensive hydrogel modification, including with multiple signals, due to the number of reactive handles accessible for secondary reaction. Hyaluronic acid was functionalized with norbornene groups (NorHA) and reacted with di-thiols to create non-toxic hydro

SUBMITTER: Gramlich WM 

PROVIDER: S-EPMC3830935 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature