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Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles.

ABSTRACT: RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.

SUBMITTER: Fang RH 

PROVIDER: S-EPMC3831007 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles.

Fang Ronnie H RH   Hu Che-Ming J CM   Chen Kevin N H KN   Luk Brian T BT   Carpenter Cody W CW   Gao Weiwei W   Li Shulin S   Zhang Dong-Er DE   Lu Weiyue W   Zhang Liangfang L  

Nanoscale 20130801 19

RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines. ...[more]