Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi K
PROVIDER: S-EPMC3831297 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Extracellular factors that inhibit axon growth and intrinsic factors that promote it affect neural regeneration. Therapies targeting any single gene have not yet simultaneously optimized both types of factors. Chondroitin sulphate (CS), a glycosaminoglycan, is the most abundant extracellular inhibitor of axon growth. Here we show that mice carrying a gene knockout for CS N-acetylgalactosaminyltransferase-1 (T1), a key enzyme in CS biosynthesis, recover more completely from spinal cord injury tha ...[more]